Peterborough vs. Oxford Utd (Saturday, 3.00pm)
The home side are currently fifth in the table, boasting 35 points from their opening 19 matches, while Oxford are third, having picked up 36 points from their first 18 games of the season.
We say: Peterborough United 1-1 Oxford United
Peterborough have not lost to Oxford in their last six competitive meetings, but the visitors are different this season. The home side have been great in front of their fans, while Oxford have been solid on the road as well. We predict a close match with the score level at the end.
Reading vs. Barnsley (Saturday, 3.00pm)
The visitors, meanwhile, will have the chance to record a second straight league victory following their recent win over Wycombe Wanderers.
We say: Reading 2-2 Barnsley
While Reading may be languishing in the relegation zone, one defeat in five competitive matches suggests the Royals may be on the up, and we think Selles's rejuvenated side will do enough to take a point off playoff-chasing Barnsley on Saturday.
Wigan vs. Lincoln (Saturday, 3.00pm)
The visitors, who occupy ninth place in the League One table, will be looking to continue their promising form and make it four games without defeat.
We say: Wigan Athletic 2-1 Lincoln City
Although Wigan have lost their last two home meetings with Lincoln, we think that they will collect all three points on this occasion, especially after winning four of their last five home league games.
Wycombe vs. Shrewsbury (Saturday, 3.00pm)
Shrewsbury Town will be aiming to extend their unbeaten run in all competitions to four matches when they travel to an out-of-form Wycombe Wanderers outfit in League One on Saturday afternoon.
The visitors are currently 12th in the table, boasting 24 points from their 20 league matches this season, while Wycombe are 15th, picking up 22 points from their opening 18 games of the campaign.
We say: Wycombe Wanderers 1-1 Shrewsbury Town
Shrewsbury are unbeaten in their last three matches with Wycombe, and the visitors will enter this match in the better form. There is no question that Wycombe have quality, though, and we are expecting a tight game on Saturday afternoon, with the points possibly being shared in a low-scoring draw.
Blackpool vs. Carlisle (Saturday, 3.00pm)
The hosts are currently in eighth place in the league standings with 30 points after 20 matches, while the visitors have managed just 15 points to date and are firmly involved in the relegation scrap.
We say: Blackpool 2-1 Carlisle United
Barring that loss to Portsmouth last time out, Blackpool have found a bit of form of late and will fancy their chances of earning another three points here against an opponent that are winless in their last four. The Seasiders will also know that a victory could take them as high as the top six, which will be exactly where they want to be heading into the busy festive period.
Bristol Rovers vs. Cheltenham (Saturday, 3.00pm)
The hosts are in 11th place in the league standings with 24 points after 18 matches, while the visitors are in all sorts of trouble, currently at the foot of the table and six points from safety.
We say: Bristol Rovers 2-1 Cheltenham Town
Bristol Rovers have already fallen a spot in the league standings in recent weeks, but they will be confident here as they return to their home patch, where they are carrying a six-match unbeaten streak. While the visitors have shown signs of life in recent weeks, we feel that The Pirates will edge this one by the odd goal.
Burton Albion vs. Stevenage (Saturday, 3.00pm)
The newly-promoted visitors sit fourth in the League One table in the midst of a seven-game unbeaten run, while their hosts have dropped to 17th spot following three straight league defeats.
We say: Burton Albion 0-2 Stevenage
While Burton Albion will hope to build on their midweek cup win with home advantage, we can only see the two sides' league runs continuing on Saturday and tip Steve Evans's side to further strengthen their position in the leading pack with a victory at the Pirelli Stadium.
Charlton vs. Cambridge (Saturday, 3.00pm)
Harris inherits a side sat 18th in the League One table following three straight defeats, while their hosts sit 10th in the midst of a four-match unbeaten run.
We say: Charlton Athletic 2-1 Cambridge United
While Cambridge United may feel some renewed confidence and optimism following their big cup win and the appointment of a new boss, they face a tough test away at a Charlton Athletic side with superior quality, and we back Appleton's men to take all three points at the Valley.
Exeter vs. Port Vale (Saturday, 3.00pm)
The hosts, who are languishing in 20th position, are only two points clear of the relegation zone, while the Valiants are just one point better off in 19th place.
We say: Exeter City 1-1 Port Vale
Both teams will be desperate to claim all three points following a poor run of results, but we think that a lack of confidence in the two squads could result in a cagey affair finishing honours even.
Leyton Orient vs. Derby (Saturday, 3.00pm)
The hosts, meanwhile, will be looking to return to winning ways after experiencing a six-game winless run in all competitions.
We say: Leyton Orient 1-3 Derby County
With the two sides experiencing contrasting spells of form, we think that a confident Derby side will get the better of Leyton Orient to claim their fifth consecutive league victory.
Northampton vs. Fleetwood (Saturday, 3.00pm)
Following back-to-back defeats, the visitors find themselves two points adrift of safety in 21st spot, while their hosts climbed to 13th spot with an upturn in form before a weekend loss.
We say: Northampton Town 2-0 Fleetwood Town
While Fleetwood have certainly shown signs of improvement on the whole under Lee Johnson, they lack confidence heading to Sixfields and may not have enough to come away with a result against Brady's side, who will be keen to return to their best after a minor setback last time out.