Monday's 4-2 success at Koln extended Leipzig's unbeaten run in the Bundesliga to 10 matches, while they have only lost once in Germany's top flight since the end of October, which is an indication of the size of the task facing Paderborn on Saturday afternoon.
A total of 58 points from 29 matches has left Leipzig in third spot in the table, two points off second-placed Dortmund but nine behind the leaders and champions Bayern.
It is difficult to imagine Bayern dropping enough points to allow Nagelsmann's side to challenge for the title, but there is no question that they will have their eyes on Dortmund in second position.
Die Roten Bullen have beaten Mainz 05 and Koln since the Bundesliga resumed in the middle of May, although they have been held by both Freiburg and Hertha Berlin.
Too many draws (10) have cost Leipzig the chance to be higher up the table at this stage, but the club's supporters will be feeling confident ahead of Saturday's contest against the league's basement side.
A third-tier outfit as recently as 2018, Paderborn secured back-to-back promotions to return to the Bundesliga for the current season, but there is no getting away from the fact that it has been a struggle for the club.
Indeed, a total of just 19 points from 29 matches has left them rock bottom, some eight points off 16th-placed Fortuna Dusseldorf and nine points behind Mainz in 15th position.
Paderborn had actually drawn three straight matches against Dusseldorf, Hoffenheim and Augsburg heading into the clash with BVB, but they were brought crashing back down to earth by Lucien Favre's side.
The newly-promoted club gave a good account of themselves in the reverse fixture with Leipzig earlier this season, though, only narrowly losing 3-2 to Nagelsmann's side at the end of November.
Leipzig Bundesliga form: DDDWDW
Leipzig form (all competitions): DWDWDW
Paderborn Bundesliga form: LLDDDL
The home side did not pick up any fresh injury concerns against Koln on Monday, though, and it would not be a surprise to see the same XI sent onto the field.
Leipzig possible starting lineup:
Gulacsi; Mukiele, Klostermann, Upamcecano, Angelino; Olmo, Sabitzer, Laimer, Nkunku; Schick, Werner
Paderborn possible starting lineup:
Zingerle; Drager, Strohdiek, Hunemeier, Jans; Zolinski, Srbeny, Schonlau, Vasiliadis, Anti-Adjej; Mamba
We say: Leipzig 3-0 Paderborn
Interestingly, Paderborn have picked up more points on their travels (11) than at home (8) this season, but it is incredibly difficult to make a case for the strugglers this weekend. Leipzig have only lost one of their 14 home Bundesliga fixtures this term, and we fancy Nagelsmann's side to pick up another three points.
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