At a time when the home side are without a victory in four games, Spezia are one spot higher in 16th position on the back of their win over Salernitana.
Having gone four matches without defeat earlier in the season, Sampdoria looked on course for an enjoyable campaign under Roberto D'Aversa.
However, collecting just one point and conceding 13 goals during their next quartet of fixtures has put a different spin on matters, Sampdoria now down in 17th position.
With Napoli and Juventus coming during that recent run, the club's supporters may be willing to have some patience, but they would have shared D'Aversa's disappointment with the 3-1 defeat at Cagliari.
Aside from next week's meeting with Atalanta BC, I Blucerchiati have a more favourable schedule in front of them with four of their next six games being staged at Stadio Luigi Ferraris.
Nevertheless, nothing will improve unless they find a solution to their issues in defence with no clean sheets being kept at their home ground.
From Spezia's perspective, a meeting with their next opponents will feel like the ideal opportunity to move clear of the bottom three.
The comeback success over Salernitana have breathed new life into their season having previously shipped nine times in defeats to Juventus, AC Milan and Hellas Verona.
Thiago Motta will not get carried away by that last result, especially given the importance of gaining more points from their next four games with a top-seven club nowhere in sight.
Like their hosts, clean sheets have not been forthcoming, and that should make for an entertaining encounter on Friday night.
Sampdoria will have to make do without Morten Thorsby after the midfielder picked up his fifth yellow card of the season last time out.
Mikkel Damsgaard missed that game with a thigh injury and will continue to be assessed this week.
Barring any late fitness issues, Motta may be prepared to stick with the side which edged out Salernitana.
Despite coming off the substitutes' bench to provide the assist for the winner, 19-year-old winger Suf Podgoreanu is likely to stay among the replacements.
Sampdoria possible starting lineup:
Audero; Bereszynski, Yoshida, Colley, Augello; Candreva, Ekdal, Silva, Askildsen; Caputo, Quagliarella
Spezia possible starting lineup:
Provedel; Ferrer, Hristov, Nikolaou, Gyasi; Kovalenko, Maggiore; Strelec, Salcedo, Antiste; Nzola
We say: Sampdoria 2-1 Spezia
Despite Spezia sitting higher in the table, you have to take into consideration where their wins have come from. With that in mind, we are backing the home team to edge this contest by the odd goal in three, moving them clear of the relegation zone.
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