Abraham - on loan from Chelsea - takes the place of Fernando Llorente, who is expected to be out of action for a couple of weeks following a cycling accident suffered on holiday.
Hosting Southampton are similarly missing a key player with an uncertain future as Virgil van Dijk is absent due to a virus.
Southampton: Forster; Cedric, Stephens, Yoshida, Bertrand; Davis, Romeu; Ward-Prowse, Tadic, Redmond; Gabbiadini
Subs: Taylor, Bednarek, McQueen, Lemina, Boufal, Long, Austin
Swansea City: Fabianski; Naughton, Fernandez, Mawson, Olsson' Britton, Fer, Carroll, Routledge; Ayew, Abraham
Subs: Nordfeldt, Rangel, Bartley, Fulton, Roque Mesa, Narsingh, McBurnie