The Lilywhites have claimed back-to-back top flight victories over Aston Villa and Newcastle United in recent weeks but fell to a dampening 1-0 Europa Conference League defeat to Vitesse in midweek.
However, Nuno Espirito Santo is now set to welcome back a well-rested Harry Kane to his starting lineup, with the England captain finally getting off the mark for the Premier League season at St James' Park last weekend.
Here, Sports Mole takes a closer look at Kane's record against West Ham ahead of Sunday's battle.
During his brief stint with Millwall, Kane found himself up against West Ham in the Championship during the 2011-12 season, as he was brought on for the final 34 minutes of the encounter but could not prevent his side falling to a 2-1 defeat.
Kane's first taste of top-flight action against West Ham actually came all the way back in the 2012-13 Premier League season with Norwich City, playing 89 minutes across both fixtures but failing to find the back of the net.
During his breakthrough 2014-15 campaign, Kane would come off the bench to assist a 93rd-minute Eric Dier winner at Upton Park before scoring his first goal against the Hammers in a 2-2 draw at White Hart Lane in February 2015.
Kane would proceed to bag two braces in a pair of 4-1 and 3-2 home wins against West Ham in the 2015-16 and 2016-17 seasons, but Spurs lost both away fixtures in those two campaigns by a goal to nil.
Spurs would then proceed to navigate three matches against West Ham without Kane finding the back of the net - although his ligament injury in the latter stages of the 2018-19 season did not help matters there - and he returned with his side's third in a 3-2 win in November 2019.
The Kane-Son Heung-min combination would come to the fore later that year against the Hammers, as the England skipper netted his side's second in a 2-0 win in North London, and he had a hand in all three of his side's quickfire goals (two strikes, one assist) in last season's 3-3 thriller.
Spurs have also faced West Ham three times in the EFL Cup during Kane's time at the club, but the striker has not been involved in any of those fixtures for various reasons, and he has only come out on the winning side in seven of his 17 encounters with the Hammers.
However, with 11 Premier League goals against West Ham, Kane has only scored more in the division against Leicester City (15), although the 28-year-old has only chalked up three of those strikes on the Hammers' turf.