Spurs, who were in the Champions League final only six months ago, have endured a tough start to the season and are currently 14th in the Premier League table.
Here, the PA news agency takes a look at Pochettino's English coaching career in pictures.
Pochettino was announced as Southampton manager in January 2013 (Chris Ison/PA)
Pochettino was appointed Tottenham head coach in May 2014 (Adam Davy/PA)
Pochettino's Tottenham were runners-up to Chelsea in the Carabao Cup final in 2015 in his first season in charge (Andrew Matthews/POOL wire)
Watford manager Quique Sanchez Flores speaks to Pochettino during their Premier League match at White Hart Lane (Adam Davy/PA)
Tottenham were in contention to win the league in 2015/16, but on May 2 2016 they drew 2–2 against Chelsea, confirming Leicester as champions (John Walton/PA)
Liverpool manager Jurgen Klopp and Pochettino shake hands prior to the Premier League between their sides at White Hart Lane in 2016 (Steve Paston/PA)
Pochettino gestures on the touchline during the Champions League match against Monaco at Wembley in September 2016 (Yui Mok/PA)
Pochettino celebrates with Tottenham goalkeeper Hugo Lloris, Harry Winks and Kieran Trippier during the Premier League match at Goodison Park in December 2018 (Peter Byrne/PA)
Pochettino celebrates after the final whistle during the UEFA Champions League semi-final against Ajax, as Spurs went through to the Madrid showpiece (Adam Davy/PA)
Pochettino led Tottenham into the Champions League final in May 2019, where they were beaten 2-0 by Liverpool (Peter Byrne/PA)
Pochettino during his last match in charge of Spurs, a 1-1 draw against Sheffield United (Bradley Collyer/PA)
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