Norwich vs. Crystal Palace (Wednesday, 7.45pm)
Seeking to extend a three-game winning streak across all competitions, Norwich City prepare to welcome Crystal Palace to Selhurst Park for Wednesday's Premier League battle.
The Canaries edged past Wolverhampton Wanderers 1-0 in the FA Cup at the weekend, while Patrick Vieira's side saw off Hartlepool United 2-0 to reach the fifth round.
We say: Norwich City 2-2 Crystal Palace
Norwich appear to have turned a corner in recent weeks and should feel capable of breaching this shaky Palace backline more than once, but the visitors' attacking talent cannot be questioned.
The emergence of Olise and expected return of Zaha will also contribute to what ought to be an enthralling affair at Carrow Road - one that we expect to end all square with plenty of goalmouth action.
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Spurs vs. Southampton (Wednesday, 7.45pm)
Having both reached the fifth round of the FA Cup, Tottenham Hotspur and Southampton now prepare for battle in the Premier League on Wednesday in the capital.
Antonio Conte's men eased past Brighton & Hove Albion 3-1 in the fourth round, while the Saints only just scraped past Coventry City 2-1.
We say: Tottenham Hotspur 2-0 Southampton
Tottenham's affinity for goals at home coupled with Southampton's inability to keep the back door shut on the road makes it difficult to envisage Hasenhuttl's men making their midweek trip to the capital worthwhile.
Conte will stress the message to his players that dropped points in games such as this one is simply not an option if they want to remain in the driving seat for a top-four place, so we can only back Spurs to prevail comfortably here.
> Click here to read our full preview for this match
> How Tottenham could line up against Southampton
> Tottenham injury, suspension list vs. Southampton
> Harry Kane's record vs. Southampton
Man City vs. Brentford (Wednesday, 7.45pm)
Manchester City will seek an immediate return to winning ways in the Premier League when Brentford pay a visit to the Etihad Stadium on Wednesday evening.
The reigning champions advanced in the FA Cup with a resounding 4-1 victory over Fulham at the weekend, but the Bees lost by the same scoreline away to Everton.
We say: Manchester City 3-0 Brentford
From the highs of beating Arsenal on the opening day to the current predicament they find themselves in, Brentford may start to look over their shoulder if this game pans out as expected.
The Bees just cannot shut up shop away from home and are visiting a Man City side in imperious form as they march towards the title, so another straightforward success surely awaits the champions in midweek.
> Click here to read our full preview for this match
> How Man City could line up against Brentford
> Man City injury, suspension list vs. Brentford
Aston Villa vs. Leeds (Wednesday, 8.00pm)
Aston Villa and Leeds United mark their returns to action following the international break with Wednesday's Premier League battle in the West Midlands.
Steven Gerrard's men saw off Everton 1-0 at Goodison Park before the international break, while the Whites went down by the same scoreline to Newcastle United.
We say: Aston Villa 2-1 Leeds United
Villa have been busy boosting their squad while Leeds' medical staff continue to welcome new faces into the treatment room, which does not bode well at all for Bielsa.
We would not put it past the Whites to make the net ripple even without Bamford leading the charge, but Villa's upwards momentum should continue with a hard-fought three points on their own turf.
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