The Dons are in action for the final time before their 2021-22 campaign begins and will be backed by more than 11,000 fans in midweek.
While rumours continue to circulate over the England international, Spurs did at least manage to tie down fellow key man Son Heung-min to a new long-term deal last week.
In terms of on-the-field activity, the Lilywhites started life under Nuno with an underwhelming 1-1 draw at Leyton Orient, before seeing off Colchester United 3-0 last time out.
Nuno will likely take the same approach to this game, but with only two more friendlies to come - against Chelsea and Arsenal - he needs to start thinking about his strongest XI.
As for the home side, they have also played a couple of friendlies this summer, thrashing Coventry City 7-1 in a behind-closed-doors game before losing 3-1 to Bristol City.
This is the last friendly Martin's men will play before facing Bournemouth in round one of the EFL Cup on Saturday, so a strong starting lineup should be fielded.
Son took just 11 minutes to find the net in his first game back for Tottenham against Colchester and should be among a number of high-profile starters for the visitors.
A number of internationals are still away after representing their countries at Euro 2020, including star man Kane.
New signing Gollini may be considered for selection, but it is more likely that academy product Alfie Whiteman will get possibly a last run-out of pre-season here.
As for MK Dons, they know that an improvement is needed on the back of their two-goal loss to second-tier opponents Bristol City.
MK Dons possible starting lineup:
Ravizzoli; Watson, Baldwin, O'Hora, Darling; Riley, Kasumu, Freeman, Twine; Eisa, Bird
Tottenham Hotspur possible starting lineup:
Whiteman; Paskotsi, Carter-Vickers, Tanganga, Omole; Skipp, Winks, White; Bergwijn, Parrott, Son
We say: MK Dons 0-2 Tottenham Hotspur
Tottenham may be far from full strength, but Nuno still has a number of world-class stars to call upon for this trip to Stadium MK.
After flexing their muscles with a 3-0 win at Colchester last week, we can see the Lilywhites seeing off the third-tier Dons with relative ease.
body check tags ::