Spurs travel to St James' Park aiming to make it back-to-back wins in the top flight as they look to bridge the three-point gap on fourth-placed Chelsea.
However, Mourinho is almost certain to be without Ben Davies for the match after the defender returned early from Wales duty with what was described as a "significant" injury.
Japhet Tanganga filled in at right-back last time out and, given the nature of the 2-0 win at Aston Villa, Mourinho may be tempted to stick with the same back four here.
Kane has been involved in 43 goals in 40 games in all competitions this term (27 goals, 16 assists), which is just two short of his best ever season in his senior career in 2017-18.
Tottenham possible starting lineup: Lloris; Tanganga, Sanchez, Rodon, Reguilon; Lo Celso, Ndombele, Hojbjerg, Lucas; Kane, Vinicius
Watch the Sports Mole Football Shorts prediction for this game below:
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