Meanwhile, the Millers play host to their promotion-chasing opponents sitting in the relegation zone, albeit with two games in hand on their rivals.
During the latter stages of 2020, Michael O'Neill would have been aware that Stoke would not continue to contend for a playoff spot unless they improved their efforts in the final third of the pitch.
With just three goals coming from their most recent six matches, O'Neill's concerns have materialised, and the Potters now sit four points adrift of the top six having played at least one more game than their rivals.
Joint top-goalscorer Nick Powell added his sixth goal of the campaign in Saturday's 1-1 draw at Blackburn Rovers, ending a run of four games without finding the back of the net.
Opponents Rotherham have played just three times in the space of a month due to issues regarding positive coronavirus cases.
Although Paul Warne would have preferred to have kept to their initial schedule, the enforced break appears to have given his players a new lease of life.
After impressing during their 2-1 defeat at Everton in the FA Cup third round, the Millers were able to collect a 1-0 victory away at relegation rivals Derby County on Saturday.
Despite remaining in the bottom three, Warne will be optimistic that being forced into a situation to recharge their batteries could benefit them against clubs who have still been playing twice a week.
Rotherham United Championship form: LLWLLW
Rotherham United form (all competitions): LWLLLW
Stoke City Championship form: DWDDLD
Stoke City form (all competitions): LDDLLD
Barring any fitness issues, Warne could select the same side which performed so impressively at the weekend.
Stoke will be without James Chester after the Wales international was sent off at Ewood Park at the weekend.
Danny Batth is in line to return to the starting lineup in what could be one of a number of changes made by O'Neill.
Rotherham United possible starting lineup:
Blackman; Olosunde, Ihiekwe, Wood, MacDonald, Harding; Lindsay, Barlaser, Wiles; Smith, Crooks
Stoke City possible starting lineup:
Bursik; Collins, Batth, Souttar; Smith, Clucas, Mikel, Thompson, Norrington-Davies; Powell, Vokes
We say: Rotherham United 1-1 Stoke City
Stoke's most recent additions should improve their efforts in the final third during the second half of the season. However, the trio of arrivals still need some bedding-in time, and we are backing the home side to claim a share of the spoils on Tuesday night.