Alan Pardew has revealed that Fraizer Campbell, Yaya Sanogo and Marouane Chamakh will all miss this weekend's match against West Ham United.
There is a further blow for Eagles supporters, as former Cardiff City and Sunderland striker Campbell is likely to miss the next five to six weeks due to an injury picked up against Arsenal last time out, while Sanogo and Chamakh are short-term absentees.
Meanwhile, Australia international Mile Jedinak, who has not featured for the South London outfit since returning from the Asia Cup earlier this month, is said to be pushing hard for a return to fitness.
Pardew comes up against one of his former players in Kevin Nolan on Saturday, and speaking in his pre-match press conference the Palace boss was quick to praise the English midfielder.
"Nolan has a fantastic record of winning games and spreads that mentality around the group," he said. "He's a credit to himself and the club and is a great role model to younger players."
Palace currently occupy 13th place in the Premier League table.