Wolverhampton Wanderers forward Diogo Jota is looking to become the first player in major Uefa competition to score a hat-trick in three successive appearances.
Having endured a poor run of form in the final third, Jota netted his first treble of the campaign in the group-stage encounter with Besiktas at Molineux.
The Portuguese matched that effort last month, contributing another three goals as the Premier League outfit registered a 4-0 triumph over Espanyol at the last-32 stage.
Given the club's commanding advantage, Nuno Espirito Santo made the decision to rest the playmaker for the second leg in Spain, putting the 23-year-old in a position to break a long-standing record against Olympiacos on Thursday night.
During 2010-11, Radamel Falcao, then of Porto, netted three hat-tricks during the club's successful Europa League campaign, which ended with a 1-0 win over compatriots Braga in the final.
The Colombian's first treble came at Rapid Vienna in the group stages, before a second hat-trick came during a home contest with Spartak Moscow.
Falcao saved his best effort until last, scoring four times during the first leg of the semi-final against Villarreal.
