The Merseyside derby headlines Wednesday's action as title-chasing Liverpool make the trip across Stanley Park to take on Everton.
That is one of six Premier League games this evening, with leaders Chelsea and champions Manchester City both also in action.
Elsewhere in Europe, it is another big day at the top of Serie A with Napoli, AC Milan and Inter Milan all playing, while Real Madrid feature in the solitary midweek La Liga game.
Below is Sports Mole's selection of predictions and previews for Wednesday's and Thursday's fixtures.