Here, the PA news agency picks out 10 other names to look out for.
The 21-year-old Greek returns to the scene of his grand slam breakthrough as a top-10 player and ATP Finals champion. No longer a surprise package, Tstisipas' big task will be to deal with the weight of expectation and keep his composure, which has been a problem at times.
The mercurial Russian's brilliant US Open, where he made it all the way to the final and pushed Nadal to five sets, sent him to the top of the list of young players likely to break the big three's slam stranglehold. A remarkable athlete for his height with stand-out defensive skills.
Still only 20, Shapovalov seems to have dealt with the choppy waters that nearly always follow a big breakthrough and come out the other side as a serious contender. With passion and exuberance in bucket-loads, the Canadian looks to be heading for the top 10.
Somewhat in the shadow of his fellow young guns, Russian Rublev was the first of them to make a slam quarter-final at the US Open in 2017. Injury set him back but the 22-year-old is on the up again and goes into the tournament on a 12-match winning streak after titles in Doha and Adelaide.
The hottest young teenage talent in tennis, 18-year-old Italian Sinner burst into the top 100 last season before producing a staggering performance to beat Alex De Minaur and win the Next Gen ATP Finals. Possesses explosive power off both wings and a competitive zeal to match.
Melbourne has not had an Australian women's singles champion since Chris O'Neil in 1978 but Barty goes in as the world number one having won her maiden grand slam title in Paris last year. A quarter-finalist at Melbourne Park 12 months ago, her profile has sky-rocketed since.
The tall Czech has been regarded as an imminent slam winner for several seasons so could this be the tournament where it finally happens? Last year Pliskova staged a remarkable comeback to beat Williams in the quarter-finals but lost a close one to Osaka. Recently hired Dani Vallverdu as coach.
Anisimova reached the fourth round in Melbourne last January as a 17-year-old and went on to make the semi-finals in Paris. Tragedy followed with the sudden death of her father and long-time coach, Konstantin, in August. Tennis understandably took a back seat but she is a huge talent with a love of the big stage.
Could there be a fairytale finish to Wozniacki's career? The Dane announced last month she will retire after the tournament at the age of 29. Melbourne finally brought her the grand slam title she craved in 2018 and it has been a tough road since. Sure to get a great reaction.
One of the hottest tickets in Melbourne, as she has been at every tournament since that remarkable Wimbledon breakthrough, will be 15-year-old Gauff. The American does not turn 16 until March and already has a WTA title to her name. Will face Venus Williams, who she beat at Wimbledon, in the first round.