The ever-present figureheads of men's tennis will meet the future in the fourth round of the French Open on Monday.
The future increasingly appears to be Italian, and 19-year-old duo Lorenzo Musetti and Jannik Sinner will get a crack at Novak Djokovic and Rafael Nadal, respectively, in the last 16.
Djokovic needed just an hour and 32 minutes to defeat Ricardas Berankis 6-1 6-4 6-1, becoming the first man in the Open era to reach the last 16 in Paris for 12 consecutive years.
Next up he faces a player in Musetti who has made it through to the fourth round on his grand slam debut.
A stand-out junior, Musetti has made a brilliant transition to senior tennis and claimed victory in his first ever five-set match, defeating fellow Italian Marco Cecchinato 3-6 6-4 6-3 3-6 6-3.
The teenager, whose flair and eye-catching one-handed backhand make him a hugely exciting player to watch, is looking forward to testing himself against one of the greats.
"I won three matches, three good matches with a lot of great opponents," he said. "We practised a lot with Djokovic, so we know each other a little bit.
"For sure there is going to be a little bit of tension, but I think it's what I'm working for since my childhood. All the sacrifice and hard work I did became reality now. So I'm just enjoying the moment and I will try to do my best."
"Talking about Lorenzo, I think it's great to see, especially for Italian fans. We have two different styles of players, two different personalities on court and off court. I think he's very, very talented... maybe more than me. Physically he is very, very strong. With the ball, he can do whatever he wants."
Nadal extended his run of consecutive matches won at Roland Garros to 33 and consecutive sets to 32 with a 6-3 6-3 6-3 victory over Cameron Norrie.
He is wary of Sinner, saying: "He's young. He's improving every week. He has big shots. It's going to be a tough one. I need to be solid. I need to be aggressive, too, because if not it's very difficult. I need to make him play from tough positions, and I can't make a lot of mistakes."
Spaniard Carlos Alcaraz, who only turned 18 a month ago, was hoping to make it a teenage triumvirate through to the last 16 but he was beaten 6-4 7-6 (3) 6-2 by German Jan-Lennard Struff.
Tenth seed Diego Schwartzman made the semi-finals last year and is having another good run, beating Philip Kohlschreiber 6-4 6-2 6-1 on Saturday.