Andy Murray's winning start to 2019 came to a halt at the Brisbane International as he was beaten 7-5 6-2 by Daniil Medvedev in their second-round meeting.
Murray, who continues to be affected by a long-term hip injury, overcame James Duckworth in his opening match of the year on New Year's Day but was comprehensively beaten by Medvedev.
The 31-year-old Briton has slipped to 240th in the world rankings following surgery on his troublesome hip and admitted after overcoming Duckworth that he does not know how much longer his career will last.
Murray put up a fight in the first set before 14 winners by Medvedev ended his resistance after 47 minutes.
A break in the first set had offered Murray, a two-time winner of the hard-court tournament, some comfort but the second was far more one-sided as Medvedev raced into a 4-0 lead.
A brief fightback that produced success in the next two games followed but Medvedev steadied to seal victory with an ace.