Novak Djokovic succumbed to a shoulder injury as his US Open title defence came to an end against Stan Wawrinka.
Meanwhile, Johanna Konta knocked out the third seed Karolina Pliskova to reach a third successive grand slam quarter-final and her first in New York.
Here, PA looks back at day seven and forward to day eight at the championships.
Shot of the day
Madison Keys bowed out but not before unleashing this forehand rocket against Elina Svitolina.
Stat of the day
Konta is the first British woman since Jo Durie in 1983 to reach the quarter-finals at Flushing Meadows.
Shock of the day
Djokovic's exit was a surprise, but he has been carrying an injury. The shock came when women's second seed Ashleigh Barty fell by the wayside, going down in straight sets to an inspired Qiang Wang of China.
Quote of the day
Villain of the day
Daniil Medvedev is still rubbing the Flushing Meadows crowd up the wrong way.
Brit watch
Konta scored one of the biggest wins of her career by beating third seed Pliskova, with celebrity fan Tom Hiddleston once again in her corner. She will face Elina Svitolina in the quarter-finals. Jamie Murray and Neal Skupski beat Denis Shapovalov and Rohan Bopanna in the men's doubles. Murray then teamed up with Bethanie Mattek-Sands to beat his old partner Bruno Soares and Nicole Melichar in the mixed.
Fallen seeds
Women: Ashleigh Barty (2), Karolina Pliskova (3), Madison Keys (10), Petra Martic (22)
Men: Novak Djokovic (1), David Goffin (15)
Order of play
Arthur Ashe Stadium:
Naomi Osaka v Belinda Bencic
Alexander Zverev v Diego Schwartzman
Marin Cilic v Rafael Nadal
Taylor Townsend v Bianca Andreescu
Louis Armstrong Stadium:
Donna Vekic v Julia Goerges
Andrey Rublev v Matteo Berrettini
Kristie Ahn v Elise Mertens
Gael Monfils v Pablo Andujar
