World number one Ash Barty reflected on a "roller coaster" six months as her US Open hopes ended in the third round.
The Australian twice served for the match in the deciding set against Shelby Rogers but could not get over the line and the American mounted a stirring comeback to win 6-1 2-6 7-6 (5).
Barty has been on the road since March, where she has endured an up and down time, winning Wimbledon and four other tournaments, but also having to retire injured in the French Open and losing in the first round at the Olympics.
Andreescu, who had only won one grand slam match in 2021 prior to arriving in New York, next faces a big test against 17th seed Maria Sakkari, who knocked out 10th seed Petra Kvitova 6-4 6-3.
The Greek afterwards defended her compatriot Stefanos Tsitsipas in the row over the length of his off-court breaks, saying: "Stefanos is very intense on the court, but he's very slow in other movements.
"He takes time to take out his racket and everything. I can see why he's late in the bathroom. I'm 100 per cent sure he doesn't do that on purpose. He has my back on everything, for sure."
Iga Swiatek admitted she is feeling the pressure of expectation but the former French Open champion became the only woman to reach at least the fourth round of every slam this year with a 6-3 4-6 6-3 victory over Anett Kontaveit.
She will next face Olympic gold medallist Belinda Bencic, who continued her fine summer with a 6-2 6-4 victory against American Jessica Pegula.