John Isner has set up a US Open quarter-final clash with Andy Murray after beating Gilles Simon in four sets.
Little separated the two opponents in the first, but Isner proved stronger in the tie-break, winning 7-2.
The second set was the most one-sided of the contest as the Frenchman won 6-3.
In a tight third set, a tie-break was needed again to determine who went ahead, and again Isner won 7-2.
A third, and final, tie-break concluded the fourth set, with Isner this time winning 7-4 to close out the match.
