Britain have no more hopefuls at the US Open after Kyle Edmund retired from his third-round meeting against Denis Shapovalov with a neck injury.
The 22-year-old was trailing 3-6 6-3 6-3 1-0 at Flushing Meadows on Friday evening when he was forced to withdraw.
Edmund, who beat Robin Haase and Steve Johnson to make it to this stage, took the first set with breaks of serve in the second and eighth games.
Young Canadian Shapovalov responded well, though, holding in the second and third sets to edge in front.
British number two Edmund was a game down in the fourth set when, after three bouts of treatment, he was forced to pull the plug on his - and his country's - hopes.
