Andy Murray is playing doubles at Wimbledon this year, while Ashleigh Barty is looking for back-to-back grand-slam titles.
Here, PA picks out five talking points ahead of the tournament at SW19.
Changing of the guard overdue
Since the turn of the century only Williams (twice) has doubled up by winning the French Open women's singles title and then triumphing at Wimbledon. Barty was something of a surprise winner at Roland Garros, claiming her first grand-slam crown, yet the Australian is widely considered to have a game more suited to grass than the clay of Paris. The 23-year-old actually quit tennis to play cricket in 2014 but has rediscovered her love for the sport and will be a major threat.
Home hopes for Konta
With Kyle Edmund struggling for form, Britain's best hopes of singles success probably lie with Johanna Konta, whose sparkling clay-court season culminated in her run to the semi-finals in Paris. The former world number four has rediscovered her chief weapons, an aggressive service game and devastating hard hitting, which went awry following her run to the last four at Wimbledon in 2017.
Marathon man Is-no more
After South African Kevin Anderson won the second-longest match in Wimbledon history, a six-and-a-half hour semi-final marathon against American John Isner with a final set which lasted almost three hours, it prompted the All England Club to change the rules. From this year, a fifth-set tie-break will be played should the score reach 12-12. It may come as a relief to Isner, who was also involved in the longest match when he beat France's Nicolas Mahut 70-68 in the fifth set of their first-round contest in 2010.