Uruguay boss Diego Alonso could leave both Edinson Cavani and Luis Suarez out of his starting XI for Friday's key World Cup contest with Ghana.
The South American nation need to beat Ghana to stand any chance of progressing to the knockout round of the competition, as they currently sit at the bottom of Group H, boasting just one point from two matches.
Both Cavani and Suarez have found it difficult to impress at the competition, and they could be named on the bench for this match, with the view to potentially making a difference in the second half.
Darwin Nunez is a certain starter in the final third of the field, and he could be joined by Maxi Gomez, who impressed off the bench in the 2-0 loss to Portugal last time out.
Head coach Alonso is expected to resist the temptation to shuffle his pack, while there are a number of undroppable players, including Federico Valverde and Rodrigo Bentancur.
Uruguay are again likely to line up with a back three, and Guillermo Varela and Mathias Olivera should get the nod in the wing-back positions for the two-time world champions.
Giorgian de Arrascaeta could again start on the bench, with Matias Vecino unlikely to lose his spot.
Meanwhile, Ronald Araujo is unlikely to be involved for a third straight match, as the Barcelona centre-back's fitness is still being managed following his thigh operation at the end of September.
Uruguay possible starting lineup: Rochet; Gimenez, Godin, Coates; Varela, Valverde, Bentancur, Vecino, Olivera; Nunez, Gomez
