Lyon coach Hubert Fournier has opted for Alexandre Lacazette and Claudio Beauvue in attack as they take on Zenit St Petersburg.
Lyon, who will be knocked out of the Champions League if they lose and Valencia beat Gent this evening, have also retained Mathieu Valbuena after he played in the 1-0 win at Troyes last weekend.
However, Jeremy Morel has dropped to the bench, with ex-Manchester United full-back Rafael also among the substitutes.
Meanwhile, group leaders Zenit have named a strong side, with Domenico Criscito starting in defence and Artyom Dzyuba leading the Russian team's attack at the Stade de Gerland.
Brazilian forward Hulk also plays for the visitors, while both Javi Garcia and Axel Witsel feature in midfield.
Lyon: Lopes, Yanga-Mbiwa, Bedimo, Jallet, Umtiti, Tolisso, Darder, Gonalons, Beauvue, Lacazette, Valbuena
Subs: Gorgelin, Morel, Rafael, Ferri, Malbranque, Mvuemba, Cornet
Zenit St Petersburg: Lodygin, Anyukov, Criscito, Lombaerts, Neto, Danny, Shatov, Javi García, Witsel, Hulk, Dzyuba
Subs: Kerzhakov, Smolnikov, Zuev, Ryazantsev, Yusupov, Evseev, Dolgov
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