Sao Paulo and Cuiaba will each be looking to bring an end to their winless starts to the Brasileiro campaign when they face off at Estadio do Morumbi on Wednesday.
The hosts have failed to win in five attempts in the league this season, while their opponents have also failed to get off the mark in their first three games.
Match preview
Sao Paulo finished fourth in the Brazilian top flight last season, but five games into the 2021 campaign they are currently in the relegation zone.
The Tricolor have drawn two and lost three of their first five games, most recently going down 2-0 to Santos at the weekend.
First-half goals from Marinho and Gabriel Pirani proved enough for Santos to see off their rivals at the Urbano Caldeira Stadium.
Hernan Crespo is therefore still seeking his first win in charge of Sao Paulo, having been appointed earlier this year after guiding Defensa y Justicia to Copa Sudamericana glory.
Sao Paulo are still battling for silverware on a couple of other fronts, but they need to get their act together in the league if they are to climb up the division.
Crespo's side are level on points with Cuiaba heading into the match, albeit with their opponents having played two games fewer.
The visitors, who are without a head coach after parting company with Alberto Valentim last month, have drawn two and lost one of their opening three fixtures.
Following a 2-2 draw with Juventude and a 1-0 loss to Fluminense, Cuiaba played out a goalless stalemate with America Mineiro last time out.
America were previously without a point, but they went closest to scoring in a low-key affair between two sides promoted last season, which leaves Cuiaba in 16th place.
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Team News
Sao Paulo have had to make do without injured players Daniel Alves, Hernanes, William and Miranda, while Robert Arboleda is on Copa America duty with Ecuador.
Eder got the nod over Pablo alongside Luciano last time out, but that may change on the back of that 2-0 loss to Santos.
Talles Costa and Antonio Galeano, both brought on against Santos, are also pushing for recalls to the starting lineup.
Cuiaba are thought to have a fully-fit squad to choose from for Wednesday's clash at Estadio do Morumbi.
Rafael Elias and Rafael Gava were replaced by Elton and Uillian Correia at half time in the 0-0 draw with America Mineiro, so changes can be expected here.
Clayson has started all three games on the left side of attack and is likely to be selected again here.
Sao Paulo possible starting lineup:
Volpi; Vinicius, Leo, Alves, Reinaldo; Rigoni, Liziero, Wellington, Sara; Pablo, Luciano
Cuiaba possible starting lineup:
Walter; Lucas, Marllon, Paulao, Uendel; Pepe, Correia, Auremir; Marques, Elton, Clayson
We say: Sao Paulo 2-1 Cuiaba
Both teams are in need of a victory to kickstart their campaigns, especially in the case of Sao Paulo as they seek a first league win under Crespo.
Cuiaba have the ability to hold their opponents to a draw, but we can see the hosts finally getting off the mark with their first three-point haul.
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