Ireland have named uncapped duo Stuart McCloskey and Josh van der Flier in the starting lineup for Saturday's Six Nations clash against England at Twickenham.

McCloskey will make his international debut at inside centre as he replaces Jared Payne, who misses out with an injury.

In addition to the personnel change, Robbie Henshaw has moved to number 13, while Van der Flier will replace injured Sean O'Brien at openside.

Keith Earls has come into the fold in place of Dave Kearney who, along with O'Brien and Mike McCarthy, will miss the remainder of the tournament.

Uncapped Ultan Dillane is given a spot on the replacements' bench, as are Cian Healy and Simon Zebo.

Ireland team to play England:

15. Rob Kearney (UCD/Leinster) 68, 14. Andrew Trimble (Ballymena/Ulster) 60, 13. Robbie Henshaw (Buccaneers/Connacht) 17, 12. Stuart McCloskey (Ballynahinch/Ulster), 11. Keith Earls (Young Munster/Munster) 47, 10. Jonathan Sexton (St Mary's College/Leinster) 58, 9. Conor Murray (Garryowen/Munster) 44, 1. Jack McGrath (St. Mary's College/Leinster) 27, 2. Rory Best (Banbridge/Ulster) Captain 91, 3. Mike Ross (Clontarf/Leinster) 56, 4. Donnacha Ryan (Shannon/Munster) 36, 5. Devin Toner (Lansdowne/Leinster) 33, 6. CJ Stander (Munster) 2, 7. Josh van der Flier (UCD/Leinster), 8. Jamie Heaslip (Dublin University/Leinster) Vice Captain 82

Replacements: 16. Richard Strauss (Old Wesley/Leinster) 14, 17. Cian Healy (Clontarf/Leinster) 56, 18. Nathan White (Connacht) 10, 19. Ultane Dillane (Corinthians/Connacht), 20. Rhys Ruddock (St Mary's College/Leinster) 7, 21. Eoin Reddan (Old Crescent/Leinster) 68, 22. Ian Madigan (Blackrock College/Leinster) 27, 23. Simon Zebo (Cork Con/Munster) 22