Dallas Cowboys running back DeMarco Murray could reportedly be out of his side's clash against the Indianapolis Colts after breaking a bone in his hand.

The 26-year-old sustained the injury in the win over the Philadelphia Eagles as he broke the fourth metacarpal bone in his left hand late in the game.

Murray has undergone surgery to amend the problem, but could still be ruled out of the match against the Colts, according to ESPN.

Joseph Randle is ready to replace Murray as the Cowboys' starting back, which could have huge implications in Jason Garrett's men's push for the playoffs.

Murray leads the NFL in rushing yards this season with 1,687, along with 11 touchdowns.