The NFL has confirmed that Von Miller will miss the first six games of the 2013 season for violating the league's substance-abuse policy.
The Denver Broncos linebacker has been appealing against the ban over the last month, with reports suggesting that the 24-year-old was trying to negotiate a four-game absence.
"The substances of abuse policy requires everyone to comply with the rules. Although my suspension doesn't result from a positive test, there is no excuse for my violations of the rules," Miller said in a statement published on NFL.com.
"I made mistakes and my suspension has hurt my team, Broncos fans, and myself. I am especially sorry for the effect of my bad decisions on others. I will not make the same mistakes about adhering to the policy in the future.
"During my time off the field, I will work tirelessly and focus exclusively on remaining in peak shape. I look forward to contributing immediately upon my return to the field and bringing a championship back to the people of Denver."
Miller was recently voted the ninth best player in the league by his peers in a poll carried out by NFL Network.