Peyton Manning has thrown for three touchdowns to help the Denver Broncos continue their 100% start to the NFL season with a 37-21 win over the Oakland Raiders.

Manning was quick to find his rhythm in the first quarter with a 55-yard drive, before picking out Eric Decker in the endzone for the first score of the night.

Matt Prater's trusty boot extended their advantage as he landed a 53-yard field goal, with rookie quarterback Terrelle Pryor lacking support for the Raiders at the other end.

Denver's offense looked unstoppable in the second quarter as Manning continued a relentless march up the field, finding Wes Walker and Julius Thomas for successive scores.

Oakland showed some signs of life before the first half closed when Pryor split the Broncos defense to find Denarius Moore for a 73-yard touchdown pass.

Manning completed the half with 15 successful passes, with six of those finding Walker, as the Raiders defense struggled to combat a Broncos offense that passed the 300-yard mark during the second quarter.

With options limited, the Raiders gave running back Darren McFadden a chance at quarterback in the second half, with the 26-year-old firing a precise 16-yard pass to Marcel Reece for a fine score.

Any hopes of a sustained Raiders response were dashed early in the fourth quarter by Ronnie Hillman, who burst over the line for the fourth Broncos touchdown of the night.

McFadden returned to running duties and made the scoreline look more respectable late on by darting into the corner for a smart score, but he could not prevent Denver from closing out a comfortable victory.