Andrew Luck threw for two fourth-quarter touchdowns as the Indianapolis Colts picked up their first win of the season against the Tennessee Titans this evening.

The Colts started brightly in Nashville, with former San Francisco 49ers running back Frank Gore scoring a one-yard touchdown before Dwight Lowery picked off Marcus Mariota and ran the ball back to the endzone.

The Titans started to fight back as Ryan Succop kicked a field goal and Mariota atoned for his interception with a TD pass to Kendall Wright.

Luck was then picked off twice in the third quarter and Tennessee punished his mistakes with scores from Antonio Andrews and Dorial Green-Beckham before another Succop field goal left the Titans 27-14 ahead at the start of the final quarter.

However, the Indianapolis quarterback responded with touchdown passes for Phillip Dorsett and Donte Moncrief to help the Colts retake the lead.

Gore then extended that lead to eight points as Chuck Pagano's side closed in on a maiden victory in 2015.

Jalston Fowler's touchdown in the dying minutes gave Tennessee hope, but the Titans failed to convert a two-point attempt as Indy held on.