Poor shooting was the downfall of the Lakers, with the side making only 35 per cent of their shots and scoring five of 37 three-point attempts.
The Wizards have lost four straight games since the NBA restarted in the Florida bubble and are on the cusp of missing out on the post-season.
Joel Embiid top scored with 30 points, while Tobias Harris added 17.
In the Western Conference play-off race, there were defeats for the Memphis Grizzlies and the San Antonio Spurs who are among the teams vying for the eighth seed.
The Grizzlies went down to the Utah Jazz 124-115, with Joe Ingles scoring 12 in the final quarter, while the Spurs were defeated by the Denver Nuggets 132-126.
Reigning champions the Toronto Raptors, who are closing in on securing the second seed in the East, made it seven wins in a row with a 109-99 victory over the Orlando Magic while the Boston Celtics – third in the conference – swept past the Brooklyn Nets 149-115.