The experienced Australian duo of Brett Lee and Shane Watson have been forced to return home early from the tour of England after suffering injuries.
Fast bowler Lee and vice-captain Watson both injured their calves in the fourth one-dayer at Durham on Saturday.
Australia team Dr John Orchard said that both men are flying back to Sydney for MRI scans and further treatment.
England lead the five-match series 3-0 and will be looking for a series whitewash in the final match at Old Trafford tomorrow.