England lost captain Eoin Morgan and opener Jason Roy to injury scares in restricting the West Indies to 212 all out in their World Cup clash at Southampton.
Skipper Morgan trudged off forlornly after pulling up in what initially appeared an innocuous run to the stumps when backing up.
The 32-year-old immediately left the field with what was later confirmed to be a back spasm, while Roy suffered a hamstring complaint.
Jofra Archer spearheaded England's charge against the country of his birth, tearing into a host of former age-grade team-mates.
The 24-year-old quick bagged three for 30 from nine overs as England took control at the Hampshire Bowl.
Jos Buttler assumed the captaincy with Morgan off the field, and the big-hitting Lancashire star would also be a strong contender to open the batting in Roy's absence.
Roy did not field for the remainder of England's innings after suffering his own injury issue, and England opted to push him down from the top of their batting order to number seven.
That left the tournament hosts and favourites needing a new opener, with Buttler and Joe Root the top candidates.
At the interval England released a medical update on Morgan, revealing that the skipper had suffered a back spasm.
Having been off the field for 28 minutes he would not be able to bat for the same amount of time in the England innings. There was no indication that he would not be fit to do so.
England will hope for good news on both, with any extended break for either man likely forcing the management into a call-up.
As well as Archer's impressive figures, Mark Wood claimed three for 18 as England capitalised on winning the toss and bowling first.
The West Indies lost their last four wickets for 10 runs in five overs, winding up all out in the 45th over.
Barbados-born to a Liverpudlian father, Archer entered the tie under the scrutiny of taking on a host of friends and acquaintances.
Head coach Floyd Reifer insisted facing Archer's pace would be "nothing new" for the West Indies, but they were unable to handle his express seaming.
Archer dismissed Nicholas Pooran and Sheldon Cottrell with consecutive balls, but could not claim a hat-trick.
Root took two key wickets with a neat cameo too, leaving England in charge at the interval.
