West Indies require 192 runs against England to claim victory in the third Test in Barbados.
The Windies sent their opponents packing for 123 prior to lunch thanks in large to the bowling of Jason Holder and Veerasammy Permaul, who took two wickets apiece, before Jerome Taylor compounded the tourists' woes.
Gary Ballance and Ben Stokes added 23 runs to England's tally, which stood at 39-5 overnight following a West Indies fightback, but the former was soon sent packing by the bowling of Permaul.
Jos Buttler (35*) helped pile on some runs, but a loss of five wickets for 84 saw England collapse, with Holder dismissing Chris Jordan (2) and Stuart Broad (0) with successive deliveries.
England currently lead the series 1-0.