Defending champion Egan Bernal admitted his back injury is still bothering him on the eve of the Tour de France.
Bernal, 23, goes into the race as the sole leader of the Ineos Grenadiers after the decision to leave Chris Froome and Geraint Thomas at home.
But though he looked strong in winning La Route d'Occitanie and coming second in the Tour de l'Ain earlier this month, he withdrew early from the Criterium du Dauphine with back problems which continue to linger.
That was seen as mind games in some quarters as Ineos enter what could be a transitional period, moving away from Froome and Thomas to focus on the youth of Bernal as well as Richard Carapaz, 27, and Pavel Sivakov, 23.
But Brailsford insisted he had every confidence in his team in the here and now.
"Whilst it's been a fantastic journey and for the rest of the season we'll focus on Chris and Geraint, for now it's all focused on here and I'm very, very confident in the team we have here," he said.
"We've won this race more than any other team here, we've got riders in this race with more experience and who have won more Grand Tours than any other team in this race.
"Our collective knowledge of how to win the Tour de France is greater than anywhere else, so we're very, very confident about that."
The Tour will begin against a backdrop of rising coronavirus cases in France with Nice – site of the Grand Depart – put on red alert on Thursday.
Brailsford said sport was a "key part" of a relative return to normality, but accepted there could be no guarantees the event would make it to Paris on September 20.
"Everybody wants the event to happen," he said. "But equally, to take a mature and fair common-sense approach, if there becomes a point where it's too much of a risk to riders, to teams and to society in general, people need to take that on board as well."