Chile vs. Bolivia (Friday, 10.00pm)
Their opponents will look to bounce back in a positive way, after they fell to a 3-1 defeat to Venezuela in their opening encounter.
We say: Chile 2-0 Bolivia
Even despite the older age profile of their squad, we fancy Chile to comfortably get past this Bolivia outfit on Friday.
We may see fatigue kick into this ageing side later in the tournament, but for now, they should get off to a positive start.
Argentina vs. Uruguay (Saturday, 1.00am)
Argentina and Uruguay square off in Copa America action on Saturday, in a clash between the two favourites to qualify out of group B.
Argentina kicked off their campaign with a slightly disappointing 1-1 draw with Chile, while their opponents are yet to play, and will look to begin with what would be a huge win.
We say: Argentina 1-1 Uruguay
As both sides go into their toughest game of the group stage on Saturday, we cannot quite split them.
Neither will look to risk losing, likely making this a cagey affair as they each look to come away with a result and defeat the weaker sides in the group to book their spot in the final eight.