Lionel Scaloni may be tempted to ring the changes following his side's early-competition setback, knowing that there is now little margin for error.
Here, Sports Mole looks at how Argentina could line up at Estadio Mineirao.
Sergio Aguero has faced calls to be dropped after firing another blank last time out, leaving him with a return of three goals in his last 23 competitive matches for his national side.
Scaloni has showed faith in the Manchester City striker in the past, however, and that is expected to be the case on Thursday.
Having been hauled off at half time in the defeat to Colombia, meanwhile, Angel di Maria now faces a battle to win back his place.
Should Scaloni opt for a more solid four-man midfield then Rodrigo de Paul, the man brought on for Di Maria, is a contender to start.