While their last visit to the north side of the capital resulted in a 2-0 triumph over Tottenham Hotspur, Chelsea followed that result with a 2-0 defeat at home to Southampton on Boxing Day.
Despite Frank Lampard's side remaining in fourth position in the standings, the Blues are now under pressure again to retain their grip of the final Champions League place.
Here, Sports Mole rounds up their latest injury and suspension news ahead of the showdown in England's capital.
Status: Minor doubt
Type of injury: Ankle
Possible return date: December 29 (vs. Arsenal)
James was in line to feature against Southampton on Boxing Day, only for a minor ankle problem to keep him sidelined. However, the youngster may feature on the bench on Sunday.
Type of injury: Achilles
Possible return date: Unknown
While he remains at least a month away from being in contention, Loftus-Cheek has progressed onto making an appearance on the training pitch in his bid to recover from a serious Achilles injury.
CHELSEA'S SUSPENSION LIST
Chelsea have no players suspended for this fixture.