Aaron Ramsey and James Collins have pulled out of the Wales squad for Wednesday's friendly against the Republic of Ireland in Cardiff.
Arsenal midfielder Ramsey has been forced to miss the match with a ankle injury, while West Ham United defender Collins is struggling with a knee problem.
Andrew Crofts and Jazz Richards have been called in as replacements by manager Chris Coleman.
Ireland ran out comfortable 3-0 winners when the two British nations last met in 2011.