Spurs are unbeaten in nine top-flight matches and head into the weekend sitting top of the Premier League table, ahead of champions Liverpool on goal difference.
Their visitors are faring much worse, though, with Arsenal winning only one of their last six league games and sitting 14th ahead of their short trip to the Tottenham Hotspur Stadium.
Here, Sports Mole looks at how Jose Mourinho could set his side up for the contest.
Tottenham's biggest fitness concern ahead of this match surrounds Harry Kane, who missed Thursday's Europa League trip to Austria with an apparent muscle problem.
Mourinho has talked up the possibility of his talisman being fit, though, insisting that he believes he will have the Premier League's leading assist-maker available for the derby.
If he does recover in time, Kane could make history in this fixture with just one goal needed to become the North London derby's outright all-time leading goalscorer.
It was Toby Alderweireld who got the winner when the two sides last met and he is also a doubt for this game, although Mourinho suggested that the Belgian could be back available for this one after missing the last three games.
Whether he throws him straight back in from the start given the packed fixture schedule ahead of them remains to be seen, but Mourinho may look to name as close to the XI which started against Manchester City as possible again here.
Sergio Reguilon is also expected to shake off a knock in time to make his North London derby debut, while Carlos Vinicius should be available as back-up to Kane despite a question mark also hanging over his head.
Erik Lamela is the only guaranteed absentee, but Mourinho appears to have now settled on his favoured attacking trio behind Kane with Steven Bergwijn and Tanguy Ndombele starting the last two league games against Man City and Chelsea.
Son Heung-min played 82 minutes against LASK Linz in midweek but should start again, having scored in that game to take his tally for the season to 12 in all competitions - among Premier League players, only Kane and Dominic Calvert-Lewin have more.
Watch the Sports Mole Football Shorts prediction for this game below:
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