The 33-year-old, who recently signed a contract extension, missed Saints' winning return to action at Norwich through a muscle complaint.
Moussa Djenepo remains suspended for Southampton following his March sending off against Newcastle.
Arsenal will be without a host of first-team regulars when they head to Southampton on Thursday night.
David Luiz serves the last of a two-game ban while fellow defenders Pablo Mari (ankle), Calum Chambers (knee) and Cedric Soares (facial) miss out although Sokratis Papastathopoulos is fit following a thigh strain.
Southampton provisional squad: McCarthy, Gunn, Lewis, Walker-Peters, Valery, Vestergaard, Stephens, Bednarek, Danso, Bertrand, Vokins, Romeu, Ward-Prowse, Armstrong, Hojbjerg, Smallbone, Boufal, Redmond, Tella, Long, Ings, Adams, Obafemi.
Arsenal provisional squad: Martinez, Macey, Bellerin, Sokratis, Holding, Mustafi, Kolasinac, Tierney, Xhaka, Guendouzi, Ceballos, Maitland-Niles, Willock, Ozil, Nelson, Pepe, Aubameyang, Lacazette, Nketiah.