The attacker only returned from international duty on Thursday and is therefore rested and replaced by Danny Welbeck, who returns from a groin injury, in one of four changes to the side that beat Brighton & Hove Albion last time out.
Injured Aaron Ramsey is absent and Rob Holding drops to the bench, while Shkodran Mustafi misses out due to a thigh strain picked up playing for Germany. Coming in are Laurent Koscielny, Mohamed Elneny and Per Mertesacker.
Hosts Watford have made three alterations to the side that drew 2-2 with West Bromwich Albion before the international break.
Watford: Gomes; Kabasele, Mariappa, Britos; Femenia, Doucoure, Cleverley, Holebas; Pereyra, Gray, Richarlison
Subs: Karnezis, Wague, Janmaat, Watson, Capoue, Carrillo, Deeney
Arsenal: Cech; Koscielny, Mertesacker, Monreal; Bellerin, Elneny, Xhaka, Kolasinac; Iwobi, Welbeck; Lacazette
Subs: Ospina, Holding, Coquelin, Wilshere, Ozil, Walcott, Giroud
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