AS Monaco boss Leonardo Jardim is already under pressure after losing his first two matches in charge of the Ligue 1 club.
Last year's runners-up lost 2-1 to Lorient on the opening day before conceding four second-half goals to Bordeaux last weekend after holding the advantage at the break.
That game saw Radamel Falcao get another 28 minutes under his belt after a serious knee injury, and Jardim could opt to risk him from the beginning of the clash against Nantes.
Les Canaris have enjoyed a fine start under coach Michel Der Zakarian, picking up four points from their opening two fixtures to sit in sixth position.
Der Zakarian could decide to name an unchanged starting lineup with a number of players still sidelined by injury.
Recent form
Nantes: WD
AS Monaco: LL
Possible starting lineups
Nantes: Dupe, Veigneau, Vizcarrondo, Hansen, Djilobodji, Cissokho, Audel, Deaux, Veretout, Gakpe, Aristeguieta
Monaco: Subasic, Raggi, Echiejile, Abdennour, Fabinho, Toulalan, Joao Moutinho, Kondogbia, Ocampos, Berbatov, Falcao
Sports Mole says: 1-1