The visitors are currently ninth in the division, four points behind sixth-placed West Ham United with two games in hand over the Hammers, while Brighton's recent form has allowed them to move away from danger and into 15th position, now 10 points clear of the relegation zone.
Brighton saw their FA Cup journey for the 2020-21 campaign come to an end on Wednesday evening as they suffered a 1-0 defeat to Leicester City, with Kelechi Iheanacho scoring the winner in the 94th minute of the contest at the King Power Stadium.
Graham Potter's side have been on an excellent run in the Premier League, though, winning three of their last five and remaining unbeaten in the process to move clear of the relegation zone.
The Seagulls are currently 15th in the table, 10 points clear of 18th-placed Fulham, and it is difficult to imagine them being pulled into trouble once again, particularly considering their performances in recent weeks.
Brighton were held to a 1-1 draw at Burnley last weekend but have beaten Leeds United, Tottenham Hotspur and Liverpool in three of their last five top-flight fixtures and will therefore enter Saturday's clash full of confidence despite Villa's quality.
Potter's team have been better on their travels this season, though, with 16 of their 25 points coming away from the Amex, while they have won just one Premier League game on home soil in 2020-21.
Dean Smith's side have struggled for consistency in recent weeks, losing three and winning three of their last six league matches, but a brilliant campaign to date has seen them collect 35 points from 21 matches to occupy ninth position in the table.
Villa also have two games in hand over the likes of West Ham, Chelsea and Liverpool, placing them in a strong position to potentially claim European football; the gap to fourth-placed Liverpool is actually only five points with two games in hand, which is an indication of how impressive they have been this term.
Only Manchester City (15), Manchester United (13) and Leicester (13) have won more Premier League games than Smith's team (11) this term, and they have been strong on their travels, picking up 19 points from 11 matches.
There have only actually been three previous Premier League meetings between these two sides, and Brighton recorded a 2-1 victory when the pair locked horns at Villa Park back in November.
Brighton & Hove Albion Premier League form: LWDWWD
Brighton & Hove Albion form (all competitions): WDWWDL
Aston Villa Premier League form: LWLWLW
Brighton will again be without the services of Florin Andone, Tariq Lamptey, Alireza Jahanbakhsh and Solly March on Saturday, but Adam Webster and Davy Propper could be involved following recent injuries.
There are not expected to be many surprises in the away side's starting XI this weekend, with Jack Grealish, Ross Barkley and Bertrand Traore again likely to operate behind Watkins, who scored his 10th Premier League goal of the campaign against the Gunners last weekend.
Brighton & Hove Albion possible starting lineup:
Sanchez; White, Dunk, Webster; Veltman, Gross, Bissouma, Burn; Mac Allister, Maupay, Trossard
Aston Villa possible starting lineup:
Martinez; Cash, Konsa, Mings, Targett; Luiz, McGinn; Traore, Barkley, Grealish; Watkins
We say: Brighton & Hove Albion 1-2 Aston Villa
Brighton's recent form must be respected, and it would not be a surprise to see Potter's side pick up another positive result this weekend. The Seagulls have been disappointing at home, though, and we fancy a talented Villa to secure a vital three points in their pursuit of a European position.
Top betting tip
Watch the Sports Mole Football Shorts prediction for this game below: