Athletic Bilbao vs. Valencia (Wednesday, 6.00pm)
After taking one point from their first two matches, Athletic Bilbao will attempt to claim their first win of the season when they welcome Valencia to San Mames on Wednesday.
Meanwhile, Los Che are still waiting to get on the board after beginning their La Liga campaign with consecutive defeats.
We say: Athletic Bilbao 2-1 Valencia
Athletic would have been disappointed to take just one point from their first two matches, but they are usually a force to be reckoned with at San Mames, and we think that they will make full use of home advantage to condemn Valencia to a narrow defeat.
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Valladolid vs. Leganes (Wednesday, 6.00pm)
Two newly-promoted sides will face off when Real Valladolid welcome Leganes to the Estadio Jose Zorrilla for Wednesday's La Liga contest.
The hosts have three points to their name after two matches, while Leganes have begun their campaign with a win and a draw.
We say: Real Valladolid 1-1 Leganes
Leganes may be winless in six head-to-head meetings, but they played out two draws against Valladolid last season, and we think that they may take another point off Pezzolano's side in Wednesday's contest.
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Real Sociedad vs. Alaves (Wednesday, 8.30pm)
On Wednesday, Real Sociedad will attempt to claim a second straight win when they play host to fellow Basque side Alaves.
Meanwhile, the visitors are searching for their first victory of the season after taking just one point from their opening two games.
We say: Real Sociedad 2-0 Alaves
Real Sociedad would have taken confidence from Kubo's late winner in Saturday's clash with Espanyol, and we think they will build upon that result by claiming a win against an Alaves side they have beaten in three of the last five competitive meetings.
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Atletico vs. Espanyol (Wednesday, 8.30pm)
Atletico Madrid will look to maintain their unbeaten start to the season when they play host to Espanyol in Wednesday's La Liga contest.
The newly-promoted visitors are waiting to get off the mark after beginning the campaign with back-to-back defeats.
We say: Atletico Madrid 2-0 Espanyol
Atleti would have taken confidence from Sunday's commanding win over Girona, and we think that they will produce another strong home display to maintain their unbeaten start and condemn Espanyol to a third consecutive defeat.