Captain Carles Puyol has failed to recover from a knee injury in time for tonight's Champions League clash against Bayer Leverkusen.
His place in the side has been taken by Javier Mascherano, while Adriano fills in at left-back in place of Eric Abidal.
Pedro will partner Lionel Messi in attack.
Visiting Leverkusen have handed a start to winger Renato Augusto.
Barcelona: Valdes; Alves, Pique, Mascherano, Adriano; Busquets, Xavi, Cesc; Iniesta, Messi, Pedro
Leverkusen: Leno; Schwaab, Reinartz, Toprak, Kadlec; Castro, Bender, Rolfes, Renato Augusto; Kiessling, Derdiyok
