Frankfurt could also become just the third team in history to win the Europa League without losing a single game, with Glasner overseeing a 12-game unbeaten streak in the tournament so far.
Here, Sports Mole takes a closer look at Die Adler's route to the final.
GROUP D - WINNERS
The German side took seven points from their opening three games, although they needed a last-gasp Goncalo Paciencia penalty to make it past Antwerp on matchday two.
The Portuguese would also be the thorn in Antwerp's side later on in the group, netting a 94th-minute equaliser to force a 2-2 draw with the Belgian side at the Deutsche Bank Park.
Doing the double over Olympiacos and taking two points off Fenerbahce saw Frankfurt top the group with 12 points from a possible 18 - three clear of the Greek runners-up and advancing to the last-16 in the process.
LAST-16 - FRANKFURT 3-2 REAL BETIS
With Manuel Pellegrini's Real Betis side proving a tough nut to crack this term, Frankfurt's trip to the Benito Villamarin was to be anything but straightforward, although Filip Kostic got them off to the perfect start after just 14 minutes.
Betis forced extra-time when Borja Iglesias netted in the 90th minute, but with penalties looming, Guido Rodriguez and Rui Silva's mix-up saw the former turn into his own net with no less than 120 minutes on the clock to send Frankfurt through.
QUARTER-FINALS - FRANKFURT 4-3 BARCELONA
A Barcelona side with a renewed sense of confidence under Xavi entered the Europa League as one of the favourites to go all of the way in the tournament after dropping down from the Champions League.
However, Kostic's brace and Rafael Borre's effort saw Frankfurt stun the Catalans into silence, and while Barcelona responded in added time through Memphis Depay and Sergio Busquets, it was no use against Glasner's juggernaut.
SEMI-FINALS - FRANKFURT 3-1 WEST HAM
Frankfurt had purchased their tickets to the London Stadium for one of the most famous European nights in West Ham's history, but Glasner's side played party poopers after less than a minute in the English capital.
Knauff was allowed to drift away at the back post and finish before Michail Antonio's strike just crossed the line - despite the efforts of a scrambling Kevin Trapp - although Kamada had the simple task of walking the ball into the net to restore Frankfurt's one-goal first-leg lead.
Red cards for Aaron Cresswell and David Moyes only increased the gradient in West Ham's uphill battle during the second leg, and an insurance goal from Borre ensured that Die Adler would travel back to Seville to compete in the final.
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