The 20-year-old arrived at Barca as a £96m replacement for Neymar during the summer but made only four appearances for the club before picking up a serious hamstring injury.
Indeed, the youngster sustained the injury during his first La Liga start, but four months later he could now be in line for his second following his return to fitness.
Dembele came off the bench during the 1-1 Copa del Rey draw with Celta Vigo in midweek and may be forced to settle for a substitute appearance again, although manager Ernesto Valverde insists that he is in contention to start.
"Everyone on the list has the possibility of starting," he told reporters.
"I have already said that we have to be careful with him because he has to get involved with the team's dynamics again."
Barcelona resume league duties following the winter break sitting six points clear at the top of the table and 14 above Clasico rivals Real Madrid.