Juventus forward Alvaro Morata will start for Spain in the Euro 2016 qualifier away to Belarus in Borisov.
The ex-Real Madrid man is preferred to Valencia frontman Paco Alcacer, with Chelsea striker Diego Costa out injured.
Premier League trio Cesc Fabregas, Santi Cazorla and David Silva feature in a five-man midfield for La Roja, who are second in their group behind Slovakia.
Former Arsenal player Aleksandr Hleb starts for a Belarus team looking to close an eight-point gap on neighbours Ukraine in third place.
Belarus: Gorbunov, Shitov, Martynovich, Filipenko, Bordachev, Nekhaychik, Kislyak, Maevski, Volodko, Hleb; Kornilenko
Spain: Casillas, Juanfran, Pique, Ramos, Alba, Busquets, Cazorla, Fabregas, Pedro, Morata, Silva
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