Bolton Wanderers have made four changes to the side that edged past Doncaster Rovers on Tuesday.
Robert Hall, Matt Mills, Alex Baptiste and Andre Moritz come in for Zat Knight, David Wheater, Medo and Lukas Jutkiewicz.
Kelvin Etuhu and Liam Lawrence replace Jacob Mellis and Martin Woods for Barnsley.
The Tykes lost 1-0 to promotion chasing Burnley on Tuesday.
Bolton are currently 14th in the league, while Barnsley sit in 23rd, five points from safety.
Bolton Wanderers: Bogdan; Hutton, Mills, Ream, Baptiste; Trotter, Spearing, Hall, Lee; Moritz, Beckford
Barnsley: Steele; Kennedy, M'voto, Nyatanga, McLaughlin; Etuhu, Lawrence, Dawson, Jennings; Cywka, O'Grady.
