Botafogo vs. Patronato (Wednesday, 11.00pm)
Runaway Brasileiro leaders Botafogo will firmly expect to progress to the next stage of the Copa Sudamericana when they host Patronato on Wednesday.
The visitors, who are currently competing in the second tier of Argentinian football, were beaten 2-0 at home in last week's first leg.
We say: Botafogo 2-0 Patronato (Botafogo to win 4-0 on aggregate)
Botafogo are enjoying a remarkable season even at this early stage of proceedings, with Lage's side in pole position to win their third domestic crown as well as progress to the last eight of the Copa Sudamericana.
Patronato appear unlikely to bounce back to Argentina's Primera Division at the first time of asking, and we can envisage them falling to another 2-0 defeat to crash out of South American football here.
> Click here to read our full preview for this match
San Lorenzo vs. Medellin (Thursday, 1.00am)
The action resumes in the Copa Sudamericana on Wednesday when San Lorenzo plays host to Independiente Medellin in the second leg of their round-of-16 clash.
El Rojo Paisa will journey to the Estadio Pedro Bidegain looking to snap their run of five consecutive games without a win and turn the tie around following their first-leg defeat.
We say: San Lorenzo 1-0 Independiente Medellin
While Independiente Medellin will be looking to overturn their first-leg deficit, they take on a formidable side in San Lorenzo, who have been near impenetrable of late. Buoyed by their home crowd support, we are backing the Argentine outfit to pick up from where they dropped off last week and come out on top once again
